Cardiovascular and Metabolic Disease Center
Mitochondrial Research Affinity Collaboration-Laboratories & Engineering

Home > 0

Possible target for future therapies aimed at delaying or stopping Alzheimer's disease

  • 작성자한진
  • 작성일2006-05-02 23:59:07
  • 조회수1894
  • 첨부파일첨부파일
Researchers at Oregon Health & Science University's Neurological Sciences Institute (NSI) have located a possible target for future therapies aimed at delaying or stopping Alzheimer's disease. Specifically, the therapy would target a structure in brain cells previously identified as being heavily involved in the degenerative disease. The research was led by P. Hemachandra Reddy, Ph.D., NSI scientist and senior author of the study. The results are published in the May 1 issue of the journal Human Molecular Genetics. "This latest research more clearly demonstrates how structures, called mitochondria, in brain cells are a key part of the disease process in Alzheimer's. In fact, mitochondria appear to be a site where significant disease progression takes place," explained Reddy. "Research published by our lab in 2004 highlighted genes tied to this process. We also believe that toxins produced by the mitochondria contribute to Alzheimer's disease progression. In other words, the entire system may be one big feedback loop. Therefore, it is possible that therapies which encourage normal mitochondrial function may in fact delay or stop the disease in its early stages by breaking the loop." To conduct the research, Reddy and his colleagues studied mice that are bred to have an Alzheimer's-like neurodegenerative disease. Like human Alzheimer's patients, the brains of these mice produce elevated levels of amyloid precursor protein (APP). They also develop formations called beta amyloid plaques. By observing mitochondrial function in brain cells of these mice, Reddy and his colleagues determined that beta amyloid could be found both inside and outside of the mitochondria. Because mitochondrial oxidative damage is a hallmark of Alzheimer's, the scientists believe the higher accumulations of these substances may be responsible. In addition, the scientists found increased levels of hydrogen peroxide in the Alzheimer's mice, likely produced by the mitochondria due to the oxidative damage. "We believe that the disease produces mutant APP and beta amyloid which in turn impacts mitochondrial function. This results in increased production of hydrogen peroxide, resulting in a progression of the disease and higher levels of beta amyloid," said Reddy. "In other words -- this model appears to be a vicious cycle where damage to brain cells increases and in fact feeds upon itself." Previous and concurrent research in human tissue taken from Alzheimer's patients also confirmed increased levels of beta amyloid in brain cell mitochondria and appear to agree with these conclusions. "The findings are very significant in providing a greater understanding the mechanisms behind Alzheimer's," explained study co-author Joseph F. Quinn, M.D., a clinical neurologist at the Layton Center for Aging & Alzheimer's Disease Research at OHSU and an associate professor of neurology, and cell and developmental biology in the OHSU School of Medicine. "In fact, OHSU is involved in a study funded by the National Institute on Aging of antioxidant therapy for Alzheimer's including antioxidants directed at the mitochondria." While the human studies are launched, Reddy and his colleagues will continue complimentary studies in the mouse models for Alzheimer's to determine whether the oxidative damage to mitochondria can be prevented in early stages of disease progression.
Total404 [ page1/27 ]
No. 제목 작성자 작성일 조회수
404 인제대, 과기정통부 ‘2023년도 기초연구실 지원사업’ 선정 2023.09.13 관리자 (web_admin) 2023.09.13 7
403 인제대 교수팀 '돌연사 주범 심부전 원인 규명' 2023.09.13 관리자 (web_admin) 2023.09.13 5
402 2022학년도 인제학술상 수상자 선정 결과 2023.01.05 관리자 2023.01.05 57
401 안전관리 우수연구실 인증 취득 2023.01.05 관리자 2023.01.05 40
400 한진교수 화의자의학상 수상 2023.01.05 관리자 2023.01.05 57
399 이온통로 학회 -Amy 포스터상 수상 2019.01.15 김형규 2019.01.15 2,587
398 센터 겸임교수 조성우 교수 - 한빛사 -JACC Vascular Imaging 2018.12.08 김형규 2018.12.08 2,791
397 2017 IMPACT Symposium 개최 첨부파일 2017.10.31 김보현 2017.10.31 2,588
396 경암바이오유스 2017 첨부파일 2017.08.11 김보현 2017.08.11 2,871
395 KORUS 2017 첨부파일 2017.06.21 김보현 2017.06.21 2,986
394 IMPACT 2016 심포지엄 개최 안내 첨부파일 2016.04.18 관리자 2016.04.18 4,000
393 IMPACT 2015 심포지엄 개최 안내 첨부파일 2015.04.20 서대윤 2015.04.20 2,869
392 2015 중점연구소 성과 전시회 첨부파일 2015.03.31 김형규 2015.03.31 2,462
391 Best Miso Award - 한진 2014.11.04 이정훈 2014.11.04 2,072
390 신진생리학자상 - 김형규 2014.10.29 이정훈 2014.10.29 1,816
처음이전1 2 3 4 5 6 7 8 9 10 다음 마지막