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mitochondrial respiration

  • 작성자한진
  • 작성일2006-05-31 14:45:12
  • 조회수7414
  • 첨부파일첨부파일
Capsaicin induces apoptosis by inhibiting mitochondrial respiration Megan Rauscher Reuters Health Posting Date: September 9, 2002 Last Modified: November 1, 2001 Last Updated: 2002-09-09 11:17:23 -0400 (Reuters Health) NEW YORK (Reuters Health) - Scientists have discovered that capsaicin, the pungent constituent of hot chili peppers, and a more potent structurally related vanilloid found in the plant Euphorbia called resiniferatoxin, induce apoptosis of tumor cells by inhibiting mitochondrial respiration, in effect starving them of oxygen. "Capsaicin can prevent cancer development in animal models and cause cancer cell death in cultured tumor cells," Dr. Reuben Lotan of the University of Texas M. D. Anderson Cancer Center in Houston told Reuters Health. "But the mechanism underpinning this effect has not been elucidated. Our study addressed the mechanism by which capsaicin induces cancer cell death." In the September 4th issue of the Journal of the National Cancer Institute, Dr. Lotan and Dr. Numsen Hail, Jr., report that when they exposed human cutaneous squamous cell carcinoma (SCC) cells to capsaicin or resiniferatoxin for 12 hours, the majority of cells died. The apoptotic effects appeared to be triggered by inhibition of mitochondrial respiration as evidenced by an increase in the permeability of the inner mitochondrial membrane. Exposure to either capsaicin or resiniferatoxin led to a "rapid increase in hydroperoxide generation and a decrease in oxygen consumption," the team reports. This shows that "capsaicin and resiniferatoxin act at the level of oxygen consumption (respiration) in mitochondria and this causes cells to die," Dr. Lotan told Reuters Health. When they exposed respiration-deficient clones of human SCC cells to capsaicin or resiniferatoxin, the cells released less hydroperoxide compared with control cells and were resistant to mitochondrial permeability and the induction of apoptosis. The demonstrated apoptogenic and antiproliferative effects of these two compounds "warrant further studies in animal models and, if positive, also in clinical trials to assess the potential application of capsaicin or resiniferatoxin against skin cancer," Dr. Lotan said. In a JNCI editorial, Dr. Young-Joon Surh of Seoul National University in South Korea congratulates the scientists for their elegant series of experiments demonstrating that the "oxidative stress that is stimulated by vanilloid treatment of SCC cells is primarily of mitochondrial origin and contributes to the death of these cells by apoptosis." Dr. Surh also urges further study, particularly to see if the increased oxidative stress brought on by vanilloids may have harmful effects on nonmalignant cells. "If this is the case, the vanilloids would be metabolic poisons rather than valuable candidates for use in preventive therapy for skin cancer or other cutaneous disorders," the researcher cautions. J Natl Cancer Inst 2002;94:1263-1265,1281-1292.
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No. 제목 작성자 작성일 조회수
15 프로테오믹스 연구의 최신동향과 활용 첨부파일 2005.01.25 주현 2005.01.25 2,019
14 연구와 마켓 - nanobiotechnmologes applications, 마켓 그리고 회사들 2005.01.25 이현숙 2005.01.25 1,997
13 스웨덴 과학자들이 부분적으로 노화의 미스테리를 풀었다. 2005.01.25 이현숙 2005.01.25 2,117
12 STKE : the mitochondria으로부터의 칼슘 신호전달 2005.01.25 이현숙 2005.01.25 2,435
11 drug의 힘 2005.01.25 이현숙 2005.01.25 2,033
10 MFIC의 microfluidizer procesor는 thechnion에서 Mitochondrial 연구를 운행한다. 2005.01.25 이현숙 2005.01.25 3,043
9 Primagen은 과학적인 연구 사용을 위한 Retina Mitox Mitochondrial(TM) DNA Blood Test로 진단하는 탐색법을 제공한다. 2005.01.25 이현숙 2005.01.25 2,080
8 노화에서 유전자 손상의 중요 인자 첨부파일 2005.01.25 김현주 2005.01.25 1,706
7 미토콘드리아와 장수 첨부파일 2005.01.25 김현주 2005.01.25 1,738
6 미토콘드리아와 당뇨병의 관계 첨부파일 2005.01.25 김현주 2005.01.25 1,693
5 새로운 과학 분야는 세상에서 가장 치명적인 퇴행성 질환의 치료에 주력하고 있다. 첨부파일 2005.01.25 김현주 2005.01.25 1,815
4 apoptosis에 있어서 세포의 mitochondria의 역할 첨부파일 2005.01.25 이영숙 2005.01.25 2,810
3 mitochondrial DNA mutation이 혈압과 콜레스테롤 수치에 직접적으로 영향을 미친다. 2005.01.25 이영숙 2005.01.25 2,516
2 미토콘드리아 DNA변이와 노호의 관계 2005.01.25 이영숙 2005.01.25 1,949
1 bipolar disorder (BD: 양극성장애)과 mitochondria의 관계 2005.01.25 이영숙 2005.01.25 2,311
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