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Mitochondrial Medicine

  • 작성자한진
  • 작성일2006-08-24 09:47:17
  • 조회수3524
Edited by Salvatore DiMauro, Michio Hirano, and Eric A. Schon. 348 pp., illustrated. Abingdon, England, Informa Healthcare, 2006. $229.95. ISBN 1-84214-288-7. Rolf Luft described the first case of mitochondrial disease in 1962, and for more than 25 years, disorders affecting the "batteries" of the cell were confined to research papers and neurology grand rounds. The sequencing of the mitochondrial genome and the recognition in the 1980s that defects of this genome cause disease sparked new interest in these disorders, but for many physicians, mitochondrial diseases still remained at the bottom of a long list of differential diagnoses. However, owing to a combination of clinical, epidemiologic, and molecular advances, all physicians now have to be aware of the clinical problems caused by dysfunction of this organelle. Mitochondrial Medicine offers the first comprehensive description of the clinical importance of mitochondrial dysfunction in all branches of medicine. As such, its chapters trace the evolution of mitochondrial diseases, from an extremely rare group of neurologic disorders with almost uninterpretable acronyms to a group of diseases that all doctors and medical students should know about. Mitochondria are the products of two genomes (mitochondrial and nuclear), and the biochemical mechanisms involved in the generation of ATP are extremely complex. This book largely (and sensibly) ignores these issues; for those interested in biochemistry and genetics, there are many good reviews. What this book does superbly is bring together all the clinical aspects into one much-needed resource. The book is edited by experts in the field and is both up-to-date and comprehensive. The editors, who contributed a number of chapters themselves, have brought together a knowledgeable collection of clinicians. The result is a very good reference for both seasoned and new clinicians wanting to learn about mitochondrial disease. Inevitably, the amount of detail varies among chapters, which reflects in part what is known about mitochondrial aspects of particular organ diseases. This variation ranges from extensive details presented in the inclusive chapters on neurology and cardiology to information in a chapter on psychiatric disorders and mitochondrial diseases that is largely anecdotal. Patients with mitochondrial diseases in whom several organ systems are involved are difficult to care for and are often dependent on a multidisciplinary team. This excellent book should become the definitive resource on clinical aspects of mitochondrial diseases. I suspect, however, that this field will be rapidly evolving, so the editors should be aware that they have started a long project that will require many updates in the future. D.M. Turnbull, M.D., Ph.D. Newcastle University Newcastle-upon-Tyne NE2 4HH, United Kingdom
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No. 제목 작성자 작성일 조회수
15 프로테오믹스 연구의 최신동향과 활용 첨부파일 2005.01.25 주현 2005.01.25 2,019
14 연구와 마켓 - nanobiotechnmologes applications, 마켓 그리고 회사들 2005.01.25 이현숙 2005.01.25 1,997
13 스웨덴 과학자들이 부분적으로 노화의 미스테리를 풀었다. 2005.01.25 이현숙 2005.01.25 2,117
12 STKE : the mitochondria으로부터의 칼슘 신호전달 2005.01.25 이현숙 2005.01.25 2,435
11 drug의 힘 2005.01.25 이현숙 2005.01.25 2,033
10 MFIC의 microfluidizer procesor는 thechnion에서 Mitochondrial 연구를 운행한다. 2005.01.25 이현숙 2005.01.25 3,043
9 Primagen은 과학적인 연구 사용을 위한 Retina Mitox Mitochondrial(TM) DNA Blood Test로 진단하는 탐색법을 제공한다. 2005.01.25 이현숙 2005.01.25 2,080
8 노화에서 유전자 손상의 중요 인자 첨부파일 2005.01.25 김현주 2005.01.25 1,706
7 미토콘드리아와 장수 첨부파일 2005.01.25 김현주 2005.01.25 1,738
6 미토콘드리아와 당뇨병의 관계 첨부파일 2005.01.25 김현주 2005.01.25 1,693
5 새로운 과학 분야는 세상에서 가장 치명적인 퇴행성 질환의 치료에 주력하고 있다. 첨부파일 2005.01.25 김현주 2005.01.25 1,815
4 apoptosis에 있어서 세포의 mitochondria의 역할 첨부파일 2005.01.25 이영숙 2005.01.25 2,810
3 mitochondrial DNA mutation이 혈압과 콜레스테롤 수치에 직접적으로 영향을 미친다. 2005.01.25 이영숙 2005.01.25 2,516
2 미토콘드리아 DNA변이와 노호의 관계 2005.01.25 이영숙 2005.01.25 1,949
1 bipolar disorder (BD: 양극성장애)과 mitochondria의 관계 2005.01.25 이영숙 2005.01.25 2,311
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