0

Cardiovascular and Metabolic Disease Center
Mitochondrial Research Affinity Collaboration-Laboratories & Engineering

Home > 0

Mitochondrial Damage Impairs Oxygen Metabolism After Intracerebral Hemorrhage

  • 작성자한진
  • 작성일2007-01-11 01:11:14
  • 조회수2141
  • 첨부파일첨부파일
By Will Boggs, MD NEW YORK (Reuters Health) Nov 01 - Mitochondrial damage around the hematoma, not ischemia, accounts for the reduced oxygen metabolism after intracerebral hemorrhage, according to a report in the October issue of Stroke. A primary reduction in brain metabolism follows ischemia, the authors explain, and this reduced brain metabolism is responsible for reduced cerebral blood flow and low oxygen extraction surrounding the hematoma. Dr. Jeong Sook Kim-Han and colleagues from Washington University, St. Louis, Missouri investigated whether mitochondrial function was impaired in intracerebral hemorrhage (ICH) by assessing mitochondrial respiration in perihematomal tissue removed during evacuation from 6 patients with acute spontaneous ICH compared to nonfocal tissue removed at the time of temporal lobe resection for the treatment of intractable epilepsy from 6 other patients. Tissues from ICH patients showed 40% lower oxygen consumption during state 3 respiration than control tissues, the researchers report. State 4 respiration was also reduced, the investigators say, reflecting inefficient mitochondrial energy production. State 3 and 4 respiration remained reasonable within the first 2 hours after hemorrhage, the results indicate, but mitochondria isolated after longer periods were extremely impaired. "I think the importance of this work is that it points to an entirely new concept in understanding brain injury following intracerebral hemorrhage," coinvestigator Dr. Michael Diringer told Reuters Health. "For decades it was thought that ischemia was an important cause of secondary injury in both head injury and intracerebral hemorrhage. Recent work suggests the rather than ischemia, mitochondrial function is an important issue. The distinction is very important in that therapies directed toward ischemia are unlikely to help." "We are very early in understanding this issue," Dr. Diringer said. "There are drugs used to modulate mitochondria in animals, but further work is needed to see if they would be safe and useful in humans. Another option is to give supplemental oxygen in an attempt to improve mitochondrial function." Stroke 2006;37:2457-2462,2445.
Total405 [ page27/27 ]
No. 제목 작성자 작성일 조회수
15 프로테오믹스 연구의 최신동향과 활용 첨부파일 2005.01.25 주현 2005.01.25 2,020
14 연구와 마켓 - nanobiotechnmologes applications, 마켓 그리고 회사들 2005.01.25 이현숙 2005.01.25 1,998
13 스웨덴 과학자들이 부분적으로 노화의 미스테리를 풀었다. 2005.01.25 이현숙 2005.01.25 2,120
12 STKE : the mitochondria으로부터의 칼슘 신호전달 2005.01.25 이현숙 2005.01.25 2,436
11 drug의 힘 2005.01.25 이현숙 2005.01.25 2,034
10 MFIC의 microfluidizer procesor는 thechnion에서 Mitochondrial 연구를 운행한다. 2005.01.25 이현숙 2005.01.25 3,048
9 Primagen은 과학적인 연구 사용을 위한 Retina Mitox Mitochondrial(TM) DNA Blood Test로 진단하는 탐색법을 제공한다. 2005.01.25 이현숙 2005.01.25 2,081
8 노화에서 유전자 손상의 중요 인자 첨부파일 2005.01.25 김현주 2005.01.25 1,706
7 미토콘드리아와 장수 첨부파일 2005.01.25 김현주 2005.01.25 1,740
6 미토콘드리아와 당뇨병의 관계 첨부파일 2005.01.25 김현주 2005.01.25 1,695
5 새로운 과학 분야는 세상에서 가장 치명적인 퇴행성 질환의 치료에 주력하고 있다. 첨부파일 2005.01.25 김현주 2005.01.25 1,818
4 apoptosis에 있어서 세포의 mitochondria의 역할 첨부파일 2005.01.25 이영숙 2005.01.25 2,813
3 mitochondrial DNA mutation이 혈압과 콜레스테롤 수치에 직접적으로 영향을 미친다. 2005.01.25 이영숙 2005.01.25 2,516
2 미토콘드리아 DNA변이와 노호의 관계 2005.01.25 이영숙 2005.01.25 1,951
1 bipolar disorder (BD: 양극성장애)과 mitochondria의 관계 2005.01.25 이영숙 2005.01.25 2,314
처음 이전 21 22 23 24 25 26 27 다음마지막