Cardiovascular and Metabolic Disease Center
Mitochondrial Research Affinity Collaboration-Laboratories & Engineering

Home > 0

Mitochondrial Medicine

  • 작성자한진
  • 작성일2006-08-24 09:47:17
  • 조회수3524
Edited by Salvatore DiMauro, Michio Hirano, and Eric A. Schon. 348 pp., illustrated. Abingdon, England, Informa Healthcare, 2006. $229.95. ISBN 1-84214-288-7. Rolf Luft described the first case of mitochondrial disease in 1962, and for more than 25 years, disorders affecting the "batteries" of the cell were confined to research papers and neurology grand rounds. The sequencing of the mitochondrial genome and the recognition in the 1980s that defects of this genome cause disease sparked new interest in these disorders, but for many physicians, mitochondrial diseases still remained at the bottom of a long list of differential diagnoses. However, owing to a combination of clinical, epidemiologic, and molecular advances, all physicians now have to be aware of the clinical problems caused by dysfunction of this organelle. Mitochondrial Medicine offers the first comprehensive description of the clinical importance of mitochondrial dysfunction in all branches of medicine. As such, its chapters trace the evolution of mitochondrial diseases, from an extremely rare group of neurologic disorders with almost uninterpretable acronyms to a group of diseases that all doctors and medical students should know about. Mitochondria are the products of two genomes (mitochondrial and nuclear), and the biochemical mechanisms involved in the generation of ATP are extremely complex. This book largely (and sensibly) ignores these issues; for those interested in biochemistry and genetics, there are many good reviews. What this book does superbly is bring together all the clinical aspects into one much-needed resource. The book is edited by experts in the field and is both up-to-date and comprehensive. The editors, who contributed a number of chapters themselves, have brought together a knowledgeable collection of clinicians. The result is a very good reference for both seasoned and new clinicians wanting to learn about mitochondrial disease. Inevitably, the amount of detail varies among chapters, which reflects in part what is known about mitochondrial aspects of particular organ diseases. This variation ranges from extensive details presented in the inclusive chapters on neurology and cardiology to information in a chapter on psychiatric disorders and mitochondrial diseases that is largely anecdotal. Patients with mitochondrial diseases in whom several organ systems are involved are difficult to care for and are often dependent on a multidisciplinary team. This excellent book should become the definitive resource on clinical aspects of mitochondrial diseases. I suspect, however, that this field will be rapidly evolving, so the editors should be aware that they have started a long project that will require many updates in the future. D.M. Turnbull, M.D., Ph.D. Newcastle University Newcastle-upon-Tyne NE2 4HH, United Kingdom
Total405 [ page3/27 ]
No. 제목 작성자 작성일 조회수
375 Error bars in experimental biology 첨부파일 2011.05.02 허혜진 2011.05.02 3,128
374 파킨슨 질병은 미토콘드리아 complex 1 손상 보다 microtuble 에 의해서 생길수도... 라는 논문 2011.03.08 김형규 2011.03.08 5,383
373 운동을 안해도,운동한 것처럼 건강한 심장을 만들어 주는 유전자 2011.01.06 서대윤 2011.01.06 3,899
372 2010 ㅡmitophysiology conference, Young Investigator Award 수상 2010.11.16 김형규 2010.11.16 3,353
371 3차원 세포의 세계 2010.10.27 김민희 2010.10.27 2,641
370 인제대 '심혈관.대사질환센터' 중점연구소 선정 -연합뉴스 2010.08.10 김형규 2010.08.10 4,078
369 7월 연구노트 작성 우수상 시상 2010.08.03 김민희 2010.08.03 2,992
368 NYAS 리뷰 논문 게재 - 김형규,하승희 2010.08.02 김형규 2010.08.02 3,723
367 박원선 교수님과 최일환 교수님의 논문이 publish 되었습니다. 2010.07.09 최성우 2010.07.09 4,350
366 김형규-부티투 4회 미토콘드리아 연구의학회 best research award 수상 첨부파일 2010.07.06 김형규 2010.07.06 2,189
365 6월 연구노트 작성 우수상 시상 2010.06.28 최성우 2010.06.28 2,544
364 4th Conference of Korean Society for Mitochondrial Reaserch and Medicine 첨부파일 2010.06.17 최성우 2010.06.17 3,672
363 5월 연구노트 작성 우수상 시상 2010.05.31 최성우 2010.05.31 3,002
362 안준석 - 제18회 기초의학 학술대회,학생논문발표대회 최우수상 수상 첨부파일 2010.05.28 최성우 2010.05.28 3,377
361 제 6회 논문연구계획서 발표대회: 최성우 학생 우수상 수상 첨부파일 2010.04.28 최성우 2010.04.28 2,859
처음이전 1 2 3 4 5 6 7 8 9 10 다음 마지막