0

Cardiovascular and Metabolic Disease Center
Mitochondrial Research Affinity Collaboration-Laboratories & Engineering

Home > 0

Researchers Uncover Mitochondrial Defect Involved With Inherited Cancers

  • 작성자한진
  • 작성일2007-01-11 01:15:05
  • 조회수1988
  • 첨부파일첨부파일
New York (MedscapeWire) Feb 8 — University of Pittsburgh researchers have uncovered a major new concept of how a certain type of tumor develops by linking a specific defect in mitochondria to a type of inherited tumor. The scientists, led by Bora E. Baysal, MD, PhD, and Bernie Devlin, PhD, department of psychiatry, found that a defective gene on chromosome 11q23, a region previously implicated in the progression of many solid cancerous tumors, causes a hereditary tumor called hereditary paraganglioma. Paraganglioma tumors most commonly occur in the carotid body, a small organ located in the carotid artery in the neck that senses blood oxygen levels. This discovery is important because for the first time it ties a genetic defect in mitochondria to tumor development. Results of the study appear in the February 3 issue of the journal Science. The researchers became interested in families with paraganglioma who show a peculiar inheritance pattern, which can be explained by a process called "genomic imprinting." While the genetic defect is transmitted through both mothers and fathers, tumors develop only when fathers transmit the defect. The researchers found that a gene named succinate-ubiquinone oxido-reductase (SDHD), that codes for an integral part of mitochondrial complex II, was defective in families with paraganglioma. By the researchers' reasoning, the defect is likely to cause mitochondria to fail to properly sense the oxygen levels in the cell. And, because of the oxygen-sensing defect, the carotid body is chronically stimulated to compensate for the lack of oxygen. This chronic stimulation eventually leads to cellular proliferation and tumor development. Chronic atmospheric hypoxia was previously linked to the development of paraganglioma tumors in people living at high altitudes. It is conceivable, argue the researchers, that defective oxygen sensing is a fundamental process for the progression of many common solid cancers. It is well known that lack of oxygen helps the development of more malignant cell types in common solid tumors. "This finding is important because we know that hypoxia actually helps some common forms of cancer become more hardy," said Dr. Baysal. "Most cells, and most cancer cells, are harmed by low oxygen. Low oxygen normally causes cells to self-destruct. In some cancer cells, however, the mechanism for cell death is turned off. These cells reproduce under the difficult conditions brought on by low oxygen levels. The result is that the tumor cells are more aggressive and more difficult to treat. The stressful environment of hypoxia creates a stronger tumor." According to Dr. Baysal, some types of chemotherapy and radiation treatments rely on oxygen as a reagent to destroy cancer cells. In a tumor with low oxygen levels, those therapies cannot be as effective. If the researchers' hypothesis is correct, this discovery may lead to more effective cancer treatments and have important implications for other common diseases where hypoxia is involved, such as stroke and heart attack. Thediscovery of the gene may also reveal novel "genomic imprinting" mechanisms to explain why only fathers transmit this tumor, said Dr. Baysal.
Total405 [ page3/27 ]
No. 제목 작성자 작성일 조회수
375 Error bars in experimental biology 첨부파일 2011.05.02 허혜진 2011.05.02 3,129
374 파킨슨 질병은 미토콘드리아 complex 1 손상 보다 microtuble 에 의해서 생길수도... 라는 논문 2011.03.08 김형규 2011.03.08 5,385
373 운동을 안해도,운동한 것처럼 건강한 심장을 만들어 주는 유전자 2011.01.06 서대윤 2011.01.06 3,901
372 2010 ㅡmitophysiology conference, Young Investigator Award 수상 2010.11.16 김형규 2010.11.16 3,358
371 3차원 세포의 세계 2010.10.27 김민희 2010.10.27 2,642
370 인제대 '심혈관.대사질환센터' 중점연구소 선정 -연합뉴스 2010.08.10 김형규 2010.08.10 4,078
369 7월 연구노트 작성 우수상 시상 2010.08.03 김민희 2010.08.03 2,992
368 NYAS 리뷰 논문 게재 - 김형규,하승희 2010.08.02 김형규 2010.08.02 3,726
367 박원선 교수님과 최일환 교수님의 논문이 publish 되었습니다. 2010.07.09 최성우 2010.07.09 4,351
366 김형규-부티투 4회 미토콘드리아 연구의학회 best research award 수상 첨부파일 2010.07.06 김형규 2010.07.06 2,194
365 6월 연구노트 작성 우수상 시상 2010.06.28 최성우 2010.06.28 2,544
364 4th Conference of Korean Society for Mitochondrial Reaserch and Medicine 첨부파일 2010.06.17 최성우 2010.06.17 3,673
363 5월 연구노트 작성 우수상 시상 2010.05.31 최성우 2010.05.31 3,002
362 안준석 - 제18회 기초의학 학술대회,학생논문발표대회 최우수상 수상 첨부파일 2010.05.28 최성우 2010.05.28 3,378
361 제 6회 논문연구계획서 발표대회: 최성우 학생 우수상 수상 첨부파일 2010.04.28 최성우 2010.04.28 2,859
처음이전 1 2 3 4 5 6 7 8 9 10 다음 마지막