http://www.cell.com/content/current Leading Edge Research Articles Leading Edge In This Issue [PDF] Biomedicine Select [PDF] Commentary Clearing a Path through the Patent Thicket Chris Holman [Summary] [Full Text] [PDF] Obituary Cecile Pickart 1954–2006 Daniel Finley and Keith D. Wilkinson [Full Text] [PDF] Previews Astrocytes Put down the Broom and Pick up the Baton Jeffrey S. Diamond [Summary] [Full Text] [PDF] DisA, a Busy Bee That Monitors Chromosome Integrity Erik Boye [Summary] [Full Text] [PDF] CYLD in Ubiquitin Signaling and Tumor Pathogenesis Fumiyo Ikeda and Ivan Dikic [Summary] [Full Text] [PDF] The Ataxia-ome: Connecting Disease Proteins of the Cerebellum Sandrine Humbert and Frédéric Saudou [Summary] [Full Text] [PDF] Using Isoform-Specific Inhibitors to Target Lipid Kinases Julian A. Simon [Summary] [Full Text] [PDF] Minireview The Exosome and the Proteasome: Nano-Compartments for Degradation Esben Lorentzen and Elena Conti [Summary] [Full Text] [PDF] Review The Timing of Developmental Transitions in Plants Isabel Bäurle and Caroline Dean [Summary] [Full Text] [PDF] Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling Ramin Massoumi, Katarzyna Chmielarska, Katharina Hennecke, Alexander Pfeifer, and Reinhard Fässler [Summary] [Full Text] [PDF] [Supplemental Data] A Checkpoint Protein That Scans the Chromosome for Damage at the Start of Sporulation in Bacillus subtilis Michal Bejerano-Sagie, Yaara Oppenheimer-Shaanan, Idit Berlatzky, Alex Rouvinski, Mor Meyerovich, and Sigal Ben-Yehuda [Summary] [Full Text] [PDF] [Supplemental Data] Structural Insights into Histone Demethylation by JMJD2 Family Members Zhongzhou Chen, Jianye Zang, Johnathan Whetstine, Xia Hong, Foteini Davrazou, Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman, Kirk Hansen, Yang Shi, and Gongyi Zhang [Summary] [Full Text] [PDF] [Supplemental Data] Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II Rushad Pavri, Bing Zhu, Guohong Li, Patrick Trojer, Subhrangsu Mandal, Ali Shilatifard, and Danny Reinberg [Summary] [Full Text] [PDF] [Supplemental Data] Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast Ethel Queralt, Chris Lehane, Bela Novak, and Frank Uhlmann [Summary] [Full Text] [PDF] [Supplemental Data] A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling Zachary A. Knight, Beatriz Gonzalez, Morri E. Feldman, Eli R. Zunder, David D. Goldenberg, Olusegun Williams, Robbie Loewith, David Stokoe, Andras Balla, Balazs Toth, Tamas Balla, William A. Weiss, Roger L. Williams, and Kevan M. Shokat [Summary] [Full Text] [PDF] [Supplemental Data] Perception of the Bacterial PAMP EF-Tu by the Receptor EFR Restricts Agrobacterium-Mediated Transformation Cyril Zipfel, Gernot Kunze, Delphine Chinchilla, Anne Caniard, Jonathan D.G. Jones, Thomas Boller, and Georg Felix [Summary] [Full Text] [PDF] [Supplemental Data] Nontranscriptional Regulation of SYK by the Coactivator OCA-B Is Required at Multiple Stages of B Cell Development Rachael Siegel, Unkyu Kim, Alina Patke, Xin Yu, Xiaodi Ren, Alexander Tarakhovsky, and Robert G. Roeder [Summary] [Full Text] [PDF] Glia-Derived D-Serine Controls NMDA Receptor Activity and Synaptic Memory Aude Panatier, Dionysia T. Theodosis, Jean-Pierre Mothet, Bastien Touquet, Loredano Pollegioni, Dominique A. Poulain, and Stéphane H.R. Oliet [Summary] [Full Text] [PDF] [Supplemental Data] Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis Michael A. Sutton, Hiroshi T. Ito, Paola Cressy, Christian Kempf, Jessica C. Woo, and Erin M. Schuman [Summary] [Full Text] [PDF] [Supplemental Data] Resource A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration Janghoo Lim, Tong Hao, Chad Shaw, Akash J. Patel, Gábor Szabó, Jean-François Rual, C. Joseph Fisk, Ning Li, Alex Smolyar, David E. Hill, Albert-László Barabási, Marc Vidal, and Huda Y. Zoghbi [Summary] [Full Text] [PDF] [Supplemental Data]