Research Highlights from the Nature Note : "Research Highlights" picks up important thesis and introduces summary of the thesis. Those thesis must be "new" and presented on "innovative research results". 네이처에서는 매주 새롭고 창의적인 논문을 선정, 이론을 정리해서 소개하고 있습니다. 이 중 바이오관련 연구논문을 모아 소개합니다. Nature 452, 668-669 (10 April 2008) | doi:10.1038/452668a; Published online 9 April 2008 Microbiology: Fat lazy bacilli PLoS Med. 5, e7510.1371/journal.pmed.0050075 (2008) Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum Tuberculous sputum provides a sample of bacilli that must be eliminated by chemotherapy and that may go on to transmit infection. A preliminary observation that Mycobacterium tuberculosis cells contain triacylglycerol lipid bodies in sputum, but not when growing in vitro, led us to investigate the extent of this phenomenon and its physiological basis. METHODS AND FINDINGS: Microscopy-positive sputum samples from the UK and The Gambia were investigated for their content of lipid body-positive mycobacteria by combined Nile red and auramine staining...More Cancer biology: Long-distance instructions Cell 133, 66-77 doi:10.1016/j.cell.2008.01.046 (2008) TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4 Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mechanisms. Based on clinical, functional, and molecular evidence, we show that the cytokine TGFβ in the breast tu mor microenvironment primes cancer cells for metastasis to the lungs. Central to this process is the induction of angiopoietin-like 4 (ANGPTL4) by TGFβ via the Smad signaling pathway...More