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Leading Edge Research Articles
Leading Edge
In This Issue
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Biomedicine Select
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Commentary
Clearing a Path through the Patent Thicket
Chris Holman
[Summary] [Full Text] [PDF]
Obituary
Cecile Pickart 1954–2006
Daniel Finley and Keith D. Wilkinson
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Previews
Astrocytes Put down the Broom and Pick up the Baton
Jeffrey S. Diamond
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DisA, a Busy Bee That Monitors Chromosome Integrity
Erik Boye
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CYLD in Ubiquitin Signaling and Tumor Pathogenesis
Fumiyo Ikeda and Ivan Dikic
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The Ataxia-ome: Connecting Disease Proteins of the Cerebellum
Sandrine Humbert and Frédéric Saudou
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Using Isoform-Specific Inhibitors to Target Lipid Kinases
Julian A. Simon
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Minireview
The Exosome and the Proteasome: Nano-Compartments for Degradation
Esben Lorentzen and Elena Conti
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Review
The Timing of Developmental Transitions in Plants
Isabel Bäurle and Caroline Dean
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Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling
Ramin Massoumi, Katarzyna Chmielarska, Katharina Hennecke, Alexander Pfeifer, and Reinhard Fässler
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A Checkpoint Protein That Scans the Chromosome for Damage at the Start of Sporulation in Bacillus subtilis
Michal Bejerano-Sagie, Yaara Oppenheimer-Shaanan, Idit Berlatzky, Alex Rouvinski, Mor Meyerovich, and Sigal Ben-Yehuda
[Summary] [Full Text] [PDF] [Supplemental Data]
Structural Insights into Histone Demethylation by JMJD2 Family Members
Zhongzhou Chen, Jianye Zang, Johnathan Whetstine, Xia Hong, Foteini Davrazou, Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman, Kirk Hansen, Yang Shi, and Gongyi Zhang
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Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II
Rushad Pavri, Bing Zhu, Guohong Li, Patrick Trojer, Subhrangsu Mandal, Ali Shilatifard, and Danny Reinberg
[Summary] [Full Text] [PDF] [Supplemental Data]
Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast
Ethel Queralt, Chris Lehane, Bela Novak, and Frank Uhlmann
[Summary] [Full Text] [PDF] [Supplemental Data]
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
Zachary A. Knight, Beatriz Gonzalez, Morri E. Feldman, Eli R. Zunder, David D. Goldenberg, Olusegun Williams, Robbie Loewith, David Stokoe, Andras Balla, Balazs Toth, Tamas Balla, William A. Weiss, Roger L. Williams, and Kevan M. Shokat
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Perception of the Bacterial PAMP EF-Tu by the Receptor EFR Restricts Agrobacterium-Mediated Transformation
Cyril Zipfel, Gernot Kunze, Delphine Chinchilla, Anne Caniard, Jonathan D.G. Jones, Thomas Boller, and Georg Felix
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Nontranscriptional Regulation of SYK by the Coactivator OCA-B Is Required at Multiple Stages of B Cell Development
Rachael Siegel, Unkyu Kim, Alina Patke, Xin Yu, Xiaodi Ren, Alexander Tarakhovsky, and Robert G. Roeder
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Glia-Derived D-Serine Controls NMDA Receptor Activity and Synaptic Memory
Aude Panatier, Dionysia T. Theodosis, Jean-Pierre Mothet, Bastien Touquet, Loredano Pollegioni, Dominique A. Poulain, and Stéphane H.R. Oliet
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Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis
Michael A. Sutton, Hiroshi T. Ito, Paola Cressy, Christian Kempf, Jessica C. Woo, and Erin M. Schuman
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Resource
A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration
Janghoo Lim, Tong Hao, Chad Shaw, Akash J. Patel, Gábor Szabó, Jean-François Rual, C. Joseph Fisk, Ning Li, Alex Smolyar, David E. Hill, Albert-László Barabási, Marc Vidal, and Huda Y. Zoghbi
[Summary] [Full Text] [PDF] [Supplemental Data]