0

Cardiovascular and Metabolic Disease Center
Mitochondrial Research Affinity Collaboration-Laboratories & Engineering

Home > 0

Mitochondrial DNA as a potential tool for early cancer detection

  • 작성자한진
  • 작성일2007-02-10 16:39:55
  • 조회수2017
  • 첨부파일첨부파일
Authors: Parr, Ryan L.1; Dakubo, Gabriel D.1; Thayer, Robert E.1; McKenney, Keith2; Birch-Machin, Mark A.3 Source: Human Genomics, Volume 2, Number 4, January 2006, pp. 252-257(6) Publisher: Henry Stewart Publications < previous article | next article > | View Table of Contents Key: - Free content - New Content - Subscribed Content - Free Trial Content Abstract: The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis. Both of these aspects have identified mitochondrial analysis as a vital component of medical research. Moreover, mitochondria have been implicated in the process of carcinogenesis because of their vital role in energy production, nuclear-cytoplasmic signal integration and control of metabolic pathways. Interestingly, at some point during neoplastic transformation, there is an increase in reactive oxygen species, which damage the mitochondrial genome. This accelerates the somatic mutation rate of mitochondrial DNA. It has been proposed that these mutations may serve as an early indication of potential cancer development and may represent a means for tracking tumour progression. The purpose of this review is to explore the potential utility that these mutations may afford for the identification and monitoring of neoplasia and malignant transformation where appropriate body fluids or non-invasive tissue access is available for mitochondrial DNA recovery. Specifically, prostate, breast, colorectal, skin and lung cancers are discussed. Keywords: mitochondrial DNA (mtDNA); mutations; polymorphism; cancers; homoplasmy; heteroplasmy; metabolism; biomarker; reactive oxygen species (ROS); early detection
Total406 [ page18/28 ]
No. 제목 작성자 작성일 조회수
151 Agent Protects Parkinson's Neurons From Rotenone Toxicity 2006.04.21 한진 2006.04.21 3,353
150 News Tips from The Journal of Neuroscience 2006.04.21 한진 2006.04.21 3,931
149 Mitochondria tied to bipolar disorder: study 2006.04.21 한진 2006.04.21 2,189
148 와우!! 축하합니다. 염재범 선생님 논문 2편이 출판되었습니다. (6) 2006.04.14 한진 2006.04.14 2,588
147 미토콘드리아가 대사증후군 치료 열쇠 (1) 2006.04.13 김태호 2006.04.13 3,553
146 Am J Physiol 논문 출간되었습니다. 축하합니다. (6)첨부파일 2006.04.08 한진 2006.04.08 2,291
145 축하!! 김형규 선생님 Young Scientist Award 수상 (6) 2006.04.07 한진 2006.04.07 2,062
144 First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown 2006.04.04 한진 2006.04.04 2,232
143 ADHD Drugs and Cardiovascular Risk 첨부파일 2006.04.03 한진 2006.04.03 1,917
142 고재홍, 김현주 선생님 한번 읽어봐주세요.Mitochondrial disease: Powerhouse of disease (3)첨부파일 2006.04.01 한진 2006.04.01 3,454
141 Scientist finds the speed genes 2006.03.24 한진 2006.03.24 2,199
140 New light on muscle efficiency: it is not the power-plant 2006.03.24 한진 2006.03.24 2,088
139 Recipe for perfect racehorse 2006.03.24 한진 2006.03.24 2,255
138 Toxic Chemical Saqrin Damages Genes That Control Brain, Nervous System 2006.03.19 한진 2006.03.19 5,616
137 Edison Pharma, University of Bologna and Columbia University Medical Center Establish Mitochondrial Disease Partnership 2006.03.19 한진 2006.03.19 4,513
처음 이전 11 12 13 14 15 16 17 18 19 20 다음 마지막